Profile

Prof. Luc Valliere's

Doctor Luc Vallières is a full professor in the Department of Molecular Medicine at Université Laval and a researcher in neuroimmunology in the Neurosciences axis at the CHU de Québec-Université Laval Research Center. He began his career in 2002 after a postdoctoral internship at the Salk Institute, California, in the field of postnatal neurogenesis (1998-2001). This internship was preceded by a doctorate in physiology at Laval University (1993-1998) and a bachelor's degree in biology at the University of Quebec at Chicoutimi (1990-1993). He studies two diseases that affect the central nervous system: multiple sclerosis and brain cancer. His research program aims to better understand how immune cells are regulated in these diseases, in the hope of finding a way to neutralize or stimulate them for therapeutic purposes. This program is well funded by CIHR, NSERC and the Multiple Sclerosis Society of Canada. He made significant contributions to the field of neuroimmunology by discovering a population of immune cells that constantly patrol the blood vessels of the nervous system and elucidating mechanisms that govern their recruitment and functions under inflammatory conditions. His research resulted in an international patent that claims the first-ever drug to specifically calm the neutrophil, a normally beneficial immune cell that is implicated in several inflammatory diseases. His technical background includes single cell-RNA sequencing , super-resolution STED microscopy, flow cytometry, gene editing by CRISPR-Cas9 and RNA interference, as well as bone marrow transplantation. With this expertise, he directs the super-resolution microscopy and irradiation platforms at the University Hospital of Quebec. He teaches students at all levels, notably in two courses that he directs, Principles of Neuroimmunology (MMO-7010) and Current Techniques in Molecular Medicine (MMO-7019). Among his external activities, note that he is president of the organizing committee of the 16th Congress of the International Society of Neuroimmunology, which will take place in Quebec in August 2022. He is associate editor of the journal Mediators of Inflammation . He is also an evaluator on neuroscience committees at CIHR.